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脱乙酰壳聚糖-三氟乙酸对变异链球菌的体外抑菌效果
张元鑫 , 陈小冬
大连大学 附属口腔医院 修复科,辽宁 大连 116021
摘要:
[目的]探讨脱乙酰壳聚糖-三氟乙酸(CS-TFA)复合物对变异链球菌的抑菌效果。[方法]将CS-TFA与壳聚糖(CS)分别加入变异链球菌培养基,测定各自的最小抑菌浓度,以人工唾液作对照组。取96孔板,采用对倍稀释方法用TPY液体培养基配制实验溶液,观察三组溶液对变异链球菌的抑菌效果。[结果]CS-TFA与CS的最小抑菌浓度分别为1.0 g/L与1.5 g/L,CS-TFA抑菌效果要优于CS。[结论]CS-TFA对变异链球菌有一定的抑制作用。
关键词:  脱乙酰壳聚糖-三氟乙酸  变异链球菌  抑菌
DOI:10.11724/jdmu.2011.05.07
分类号:R781.1
基金项目:
Inhibitory effect of chitosan- trifluoroacetic acid complexes on streptococcus mutans in vitro
ZHANG Yuan-xin, CHEN Xiao-dong
Department of Prosthodontics,the Affiliated Stomatology Hospital of Dalian University,Dalian 116021,China
Abstract:
[Objective]To explore the effect of chitosan-trifluoroacetic acid (CS-TFA) complex on streptococcus mutans.[Methods]CS-TFA and CS were added to mediu of streptococcus mutans to determine the minimum inhibitory concentration,the artificial saliva was used as the control group,and the experiments were diluted with TPY liquid medium for preparation of the solution.[Results]The minimum inhibitory concentration of CS-TFA and CS are 1.0 g/L and 1.5 g/L,and the antibacterial effect of CS-TFA is better than that of CS.[Conclusion]CS-TFA has inhibitory effect in streptococcus mutans.
Key words:  trifluoroacetic acid-chitosan  chitosan  streptococcus mutans  antibacterial