乳腺原发性鳞状细胞癌临床病理特征分析
Clinicopathological features of primary squamous cell carcinoma of the breast
  
DOI:10.11724/jdmu.2017.06.07
中文关键词:  乳腺鳞癌  临床特征  病理特征
英文关键词:squamous cell carcinoma of the breast  clinical features  pathological characteristics
基金项目:基金项目:河南省医学科技攻关计划项目省部共建项目(201601013);河南省人民医院23456人才工程项目
作者单位
方 斌 郑州大学人民医院(河南省人民医院) 乳腺外科河南 郑州 450003 
李文涛 郑州大学人民医院(河南省人民医院) 乳腺外科河南 郑州 450003 
翟保平 郑州大学人民医院(河南省人民医院) 乳腺外科河南 郑州 450003 
贾琳娇 郑州大学人民医院(河南省人民医院) 乳腺外科河南 郑州 450003 
司丕蕾 郑州大学人民医院(河南省人民医院) 乳腺外科河南 郑州 450003 
王 磊 郑州大学人民医院(河南省人民医院) 乳腺外科河南 郑州 450003 
姚家炳 郑州大学人民医院(河南省人民医院) 乳腺外科河南 郑州 450003 
陈 涛 郑州大学人民医院(河南省人民医院) 乳腺外科河南 郑州 450003 
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中文摘要:
      目的探讨乳腺原发性鳞状细胞癌的临床病理特点。方法收集郑州大学人民医院2009-2016年的8例乳腺原发性鳞癌患者,分析肿瘤大小、腋窝淋巴结转移情况、ER、PR、Her-2状态等指标。结果乳腺鳞癌发病率为0.33%,患者平均年龄53.75岁,肿瘤平均直径为3.9 cm。ER、PR、Her-2阳性率分别为10.4%、7.6%、10.9%,腋窝淋巴结转移率44%,8例患者均行手术治疗及化疗,8人均未行内分泌治疗及靶向治疗。术后ATCC乳腺癌TNM分期,ⅡA 4例,ⅡB 3例,ⅢB 1例。8例患者随访时间为13~72个月,平均随访时间 27.3 个月。随访结束时有3例患者失访,2例患者死亡。余3人均健在。结论乳腺鳞癌具有发病年龄大、肿瘤直径大、较低的ER、PR、Her-2阳性率、较高的AJCC分级等特点,以铂类药物为基础的化疗方案可能是较适合乳腺鳞癌的化疗方案。
英文摘要:
      Objective To investigate the clinicopathological features of primary squamous cell carcinoma of the breast. Methods Eight cases of primary squamous cell carcinoma of breast were collected in our hospital from 2009 to 2016.The tumor size, axillary lymph node metastasis, and ER, PR, Her-2 expression were analyzed. Results The incidence of breast squamous cell carcinoma was 0.33%. The average patientage was 53.75 years.All the 8 patients were treated with surgical treatment and chemotherapy.The average tumordiameter was 3.9 cm, with 44% theaxillary lymph node metastasis.ER, PR and Her-2 expression frequency were 10.4%, 7.6% and 10.9% , respectively. All patients did not receive endocrine therapy and targeted therapy.Thepatients were followed up for 13~72 months, with an average 27.3 months. At the end of follow-up, 3 patients were lost to follow-up, and 2 patients died. The remaining 3 patients are still alive.Conclusion Primary squamous cell carcinoma of the breastpatientsare relative older.Tumor diameter is large, with lower ER, PR, Her-2 positive expression frequency and high AJCC grade.Platinum based chemotherapy regimen may be better.
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