| Objective To investigate the clinical characteristic of reperfusion arrhythmia (RA) occurring in the process of percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) patients and its influence on prognosis. Methods A total of 240 patients, who were admitted in our hospital from January 2014 to December 2016 and received PCI for their acute myocardial infarction, were selected as the research objects. Analysis the clinical characteristic of reperfusion arrhythmia occurring in the process of PCI for the 240 acute myocardial infarction patients and its influence on patients' prognosis was performed. Results The incidence of reperfusion arrhythmias during PCI treatment for acute myocardial infarction was 62.50%. The incidence of slow arrhythmia in patients with high lateral wall infarction and anterior wall infarction was 10.53% and 24.56%, respectively, which was significantly lower than that in patients with posterior wall infarction (44.86%) (P<0.05). The incidence of rapid arrhythmia in patients with high lateral wall infarction was 15.79%, which was significantly lower than that in patients with anterior wall infarction (36.84%) (P<0.05). In patients with anterior wall infarction, the incidence of slow arrhythmia was significantly higher than that of rapid arrhythmia; whereas in patients with inferior posterior wall infarction, the incidence of slow arrhythmia was significantly lower than that of rapid arrhythmia (P<0.05). In patients with reperfusion time less than 6 h the incidence of RA was 72.46%, respectively, significantly higher than that of 49.02% with reperfusion time 6-12 h (P<0.05). The incidence of RA in patients with single vessel disease and three vessel disease as 84.9% and 70.7%, respectively, which was significantly higher than that of 52.1% in patients with two vessel diseases (P<0.05). There was no significant difference in the incidence of infarction and death among RA patients and non RA patients during hospitalization and follow-up (P>0.05). Conclusion In patients with acute myocardial infarction treated by PCI, the incidence of intraoperative reperfusion arrhythmias is high. The incidence varies in myocardial infarction patients with different site of infarction, reperfusion time, or number of coronary artery involved. Timely detection and effective treatment of RA obviously improve the prognosis of the patients.