| ObjectiveTo investigate the effect of dexmedetomidine on postoperative hemodynamics and analgesic sedative effect in patients with craniocerebral injury.MethodsSixty patients with craniocerebral injury from January to December in 2016, ASA I-II, were randomly divided into two groups: control group (n=30) and observation group (n=30). In the control group, patients were given routine anesthetic induction scheme. In the observation group, patients were given intravenous infusion of dexmedetomidine 1 μg/kg before induction of anesthesia and continuous intravenous pump of 0.5 μg / ( kg · h ) at 10 min after infusion until 24 hours after operation. The two groups of patients were treated with self controlled intravenous analgesia (PCIA) by sufentanil. The patients were monitored after 2 h (T1), 4 h (T2), 8 h (T3), 12 h (T4), and 24 h (T5). Hemodynamic changes, visual analogue scale (VAS), Ramsay (RSS), sedation score, and total PCIA consumption of sufentanil were recorded at each time point. The incidence of postoperative PCIA effective compressions and drug related adverse reactions were compared.ResultsCompared with the control group, the HR、MAP of T1-T4 in the observation group were significantly lower than those in the control group. The VAS score of T1-T5 was also significantly reduced. At T1, there were significant differences between the two groups in RSS sedation scores, the effective press times of PCIA decreased at T1, T2 and T3 postoperatively. T1-T2 had significantly reduced the amount of sufentanil. At the same time, the incidence of vomiting and nausea also decreased significantly. The difference between the two groups was statistically significant (P<0.05).ConclusionInfusion of dexmedetomidine in patients with craniocerebral injury not only can maintain hemodynamics and effectively reduce postoperative pain, but also can significantly reduce the postoperative sufentanil consumption and low incidence rate of adverse reaction.