| Objective To explore the value of 128-slice CT Urography in diagnosis of non-calculous urinary tract obstruction. Methods Totally 190 patients with non-calculous urinary tract obstruction underwent the thin-sliced and multi-phase contrast-enhanced CT scan. The CTU images were obtained through an independent workstation. The location and degree of urinary tract obstruction, the degree of perienal effusion and the degree of renal impairment were analyzed. Results All cases were confirmed by surgery or clinical data. Of the 190 patients, there were 51 cases of bladder cancer, 45 ureteral carcinoma, 23 retroperitoneal metastatic tumor, 15 colon cancer, 11 rectal cancer, 10 cervical cancer, 8 vascular compression, 8 renal pelvic carcinoma, 7 ovarian cancer, 6 congenital abnormality, 3 cystitis, 2 ureteritis, and 1 retroperito-neal fibrosis. Among them, there were 51cases of moderate obstruction in the middle and lower ureter and bladder outlet, severe obstruction in 119 cases, 57 cases of perirenal exudation including A grade 29 cases, B grade 24 cases, and C grade 4 cases; 37 cases of impaired renal function including mild 18 cases, moderate 10 cases, and severe 9 cases. Conclusion 128-slice CT urography has high clinical value in the localization, characterization and evaluation of the degree of obstruction, perirenal exudation and renal function of non-calculous urinary tract obstruction diseases.