| At present, the prevalence of nonalcoholic fatty liver disease (NAFLD) in China has gradually increased, and it has become one of the important public health problems. Simple lifestyle intervention and exercise have not been able to control NAFLD as expected for some patients with NAFLD. In recent years, some experimental studies, especially large randomized controlled trials, have found that some drugs have certain therapeutic effects on NAFLD, including insulin sensitizers. cholic acid drugs, antioxidants, omega-3 fatty acids, probiotics, statins, etc. This paper gives a brief review of the current domestic and international research progress in the treatment of NAFLD.