| Panic disorder (PD) is a chronic anxiety disorder, and its core features are recurrent, unexpected panic attacks (PAs) characterized by sudden, intense fear/discomfort episodes, accompanied by a surge of somatic symptoms such as dyspnea, palpitations, chest pain, and breathlessness. There are anticipatory anxiety and/or maladaptive changes in the patient’s behavior related to PAs. PD is common in clinical practice with multiple system symptoms, and frequently comorbid with other psychiatric and medical conditions. Treatment can be selected with pharmacological and psychological therapy. A good understanding of the efficacy and side effect profiles of different treatments is required by optimal management.